Based on their position in the brain and their appearance, researchers can determine which neurons will leave the ghost first or have long-term weakness for Alzheimer’s disease.
In any case, they have no idea what properties or proteins these neurons express. It is important to be aware of these elements to observe and recognize the apparent cellular adaptations that occur during infection.
A new report has now shown that neurons that signal a particular protein are more resistant to degeneration. Understanding which neurons are most vulnerable – and why – could allow scientists to prioritize planned drugs later.
To guide their study, the researchers conducted a brain scan after the death of people with Alzheimer’s disease. To understand how far the disease had progressed, they looked for a protein sauce factory in different parts of the brain.
In people with Alzheimer’s disease, tau proteins are present in all cells, so the cells usually bite the dust. Tau accumulates significantly in different areas of the brain, which explains why some areas show higher levels of degeneration.
After distinguishing the contagious movement, the experts then focused on two obvious areas of the brain: the entorhinal cortex and the predominant frontal gyrus. The entorhinal cortex is associated with memory, while the frontal gyrus, without equivalent, manages some of the capacities associated with memory.
However, tau aggregates from the entorhinal cortex in the early stages of Alzheimer’s disease do not accumulate in the dominant frontal gyrus until another time. By examining two areas of different cellular dysfunction at different stages of the disease, the researchers were able to look for contrasts in a similar cell type.
It can also enable them to reveal what makes them helpless and when they become helpless.
The researchers studied different types of neurons and cells in the entorhinal cortex and discovered how much tau they collected, as well as the proteins these cells returned.
The researchers found that a particular type of neuron – called excitatory neurons (which produce activity signals in the head) – was the most impotent of the phones they studied. They found that these neurons showed a nearly 50% reduction in their number during the early stages of Alzheimer’s disease.
Specialists have also discovered that these excitatory neurons contain larger amounts of a specific protein called RORB (retinoid-related roving receptor alpha) at the subatomic level. Since this protein was not secreted in the different cells, it shows that the properties and proteins expressed by the cell can determine its weakness.
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