College football Week 1 betting nuggets

The first week of college football is always a big one, with some teams playing their first game and others beginning the season for the third time in four years. With that in mind, we’re here to help you win your bets on all the games this weekend.

The best college football bets week 2 is a list of the best bets for Week 1 of the college football season.

Welcome to college football’s first full weekend, when we’ll get to watch several of the major contenders in action. Week 1 also features a number of notable nonconference games, such as No. 1 Alabama vs. Miami and No. 5 Georgia vs. No. 3 Clemson.

With so many games to choose from, there’s a lot to consider when selecting wins against the spread and which coaches are most likely to hit their over/unders. Let’s take a trip across the nation to get you ready for the big game.


North Carolina Tar Heels vs. Virginia Tech Hokies (-5.5, 64), 6 p.m. ET on ESPN

  • In the last 25 seasons, AP top-10 teams favored by single digits in road season openers have gone 3-10 against the spread, including five consecutive ATS defeats.

  • Over the last 20 seasons, North Carolina has gone 1-7 in season openers away from home. The Tar Heels’ lone victory over that time period came against South Carolina as a 12-point underdog in 2019.

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  • Virginia Tech is 0-9 all-time versus AP top-10 opponents in season openers, most recently falling 42-24 to No. 1 Ohio State in 2015. The Hokies are 1-5 ATS in their six games with spreads in our database.

  • When Justin Fuente plays a ranked opponent, the under is 15-6-1. (11-5-1 with Virginia Tech).

  • After two seasons as the offensive coordinator at Ole Miss, Phil Longo is in his third season as North Carolina’s offensive coordinator (2017-18). When Longo’s club is a favorite, the over is 19-9 in the last four seasons (10-7 with North Carolina, 9-2 with Ole Miss).



Noon ET on ABC, Tulane Green Wave versus No. 2 Oklahoma Sooners (-31.5, 68.5).

  • Since dropping out of the AP Top 25 for the first time since October 2016, Oklahoma has won eight straight games outright (7-1 ATS).

  • Tulane is 16-9 ATS in the last two seasons, but they are 4-5 ATS as underdogs during that time.

  • This would be the third time in Willie Fritz’s tenure that Tulane has been a 30-point underdog (since 2016). In their past two games, the Green Wave have failed to cover, including a 56-14 defeat to Oklahoma as 33-point underdogs in 2017.

  • Under Lincoln Riley, the over is 10-4-1 when Oklahoma is favored by at least 27 points (since 2017).


No. 19 Penn State Nittany Lions (-5.5, 50) take on No. 12 Wisconsin Badgers at Noon ET.

  • Since 2012, Penn State has won seven of the last nine games (7-2 SU), including four in a row (4-0 SU).

  • Last season, Penn State was 0-5 SU and ATS before winning and covering its next five games.

  • Wisconsin has gone 1-4 against the spread in its last five games at home, all as a favorite.

  • When Penn State plays a ranked opponent under James Franklin, the over is 16-5-3. (since 2014).

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Noon ET on ESPN, Western Michigan Broncos vs. Michigan Wolverines (-17, 67).

  • Michigan has an overall record of 7-0 versus Western Michigan. The Wolverines are 5-0 ATS versus the Broncos in games with spreads in our database (the average spread is Michigan -18.5). In those games, the under is 4-1.

  • In its last 15 games versus nonconference opponents, Michigan is 4-11 ATS.

  • Since 2013, Western Michigan has gone 7-1 against the spread in season openers, including 3-1 under Tim Lester.

  • In the last five seasons, when a Big Ten team is favored by less than 20 points against a MAC opponent, the under is 17-3.


No. 11 Oregon Ducks vs. Fresno State Bulldogs (-20.5, 64), 2 ET

  • Kalen DeBoer is in his second season as Fresno State’s head coach in 2021. The Bulldogs are 24-9-2 ATS and 24-11 ATS in DeBoer’s tenure with the club (as offensive coordinator from 2017-18 and as head coach the last two seasons).

  • When his team is favored by at least 14 points, Mario Cristobal is 5-11-1 ATS (3-8-1 with Oregon).

  • Since 2017, Fresno State has gone 12-4 ATS as an underdog.

  • Since 2010, the over has gone 9-1-1 in Oregon season openers.


On ABC at 3:30 p.m. ET, the No. 1 Alabama Crimson Tide (-19.5, 61.5) will face the No. 14 Miami Hurricanes.

  • Under Nick Saban, Alabama is 11-2 ATS in season openers versus FBS opponents (since 2007).

  • Alabama is favored for the 81st time in a row, the longest current winning run in the FBS. BYU has the second-longest such streak (18 straight, including this week).

  • The overall number of wins for Alabama is 11.5. For the first time since 2010, the Crimson Tide went winless in 2019. From 2011 to 2018, the over was 6-0-2.

  • Following a 9-2 ATS streak from 1979 to 1991, Miami is 3-10 ATS against AP top 2 teams since 1993 (failed to cover five consecutive).


3:30 ET on ESPN+, Miami (OH) RedHawks vs. No. 8 Cincinnati Bearcats (-22.5, 50.5).

  • Cincinnati has won 14 games in a row (9-5 ATS, including three consecutive covers).

  • The Bearcats would be favored by at least 20 points for the sixth time in a row. In the past five such games, Cincinnati has gone 1-4 ATS.

  • Since 2017, the RedHawks are 2-10 ATS against nonconference opponents in regular-season games.

  • In the RedHawks’ last ten games, the under is 8-2. (played only three games in 2020).


3:30 ET: No. 17 Indiana Hoosiers vs. No. 18 Iowa Hawkeyes (-3, 45).

  • Indiana has covered seven consecutive games as a road underdog, the second-longest run in FBS history (Oregon State has covered nine straight).

  • Indiana has covered seven consecutive conference games, which is tied for the longest current run in the FBS (Alabama).

  • Since last season, Iowa has won six consecutive games (5-1 ATS during its streak).

  • Since 2000, the over has gone 11-3 in the last 14 encounters (all available totals in our database).

  • In the last 15 seasons (all under Kirk Ferentz), the under has gone 37-16-1 in Iowa games played in September, the greatest such under percentage in FBS.


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No. 23 Louisiana Ragin’ Cajuns (-8, 58) take on No. 21 Texas Longhorns at 4:30 p.m. ET.


The Spartans of San Jose State take on the Trojans of No. 15 USC (-14, 59.5), at 5 p.m. ET.

  • Since 7.5-point underdogs against No. 13 Boise State in October 2008, the Spartans have given up the fewest points to a top-15 opponent. It would be the Spartans’ lowest point total against a top-15 opponent on the road.

  • As an underdog, San José State has covered seven consecutive games.

  • San José State has an ATS record of 12-5-3 in Brent Brennan’s third season as head coach.


7:30 p.m. ET on ABC, No. 5 Georgia Bulldogs vs. No. 3 Clemson Tigers (-3, 51).

  • Following a 20-10 ATS run from 2018 to 2019, Clemson fell 5-7 ATS in 2020.

  • Clemson is 15-4 ATS in highlighted games since 2012 (all under Dabo Swinney) (conference championship, playoff or bowl). That term may be applied to this game.

  • Under Kirby Smart, the under is 5-0 in Georgia season openers (since 2016).

  • In the last five seasons, the under has gone 15-5 in Clemson games played in September.

  • The victory total for Clemson is 11.5 points (under -135). In nine consecutive seasons, the Tigers have gone over (excluding 2020).


7:30 p.m. ET, Florida Atlantic Owls vs. No. 13 Florida Gators (-23.5, 52).

  • In its last 12 away games, Florida Atlantic is 9-3 ATS.

  • Since 2019, Florida is 7-2-1 ATS as a home favorite.

  • In its last 21 games as a double-digit favorite, Florida is 14-6-1 ATS.


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Kent State Golden Flashes at No. 6 Texas A&M Aggies (-28.5, 67), 8 ET on ESPNU

  • Jimbo Fisher is 15-4 ATS in games against nonconference opponents in the past five seasons, including 9-2 ATS with Texas A&M.

  • Six of the Aggies’ last seven season openers have been covered.

  • In its last seven games as an underdog, Kent State is 6-1 ATS.

  • Five of the Golden Flashes’ last six away games have been won.


The No. 16 LSU Tigers (-3, 65) take on the UCLA Bruins at 8:30 p.m. ET.



7:30 ET on ABC, No. 9 Notre Dame Fighting Irish (-7.5, 55.5) vs Florida State Seminoles

  • In its last six road games, Notre Dame has covered five of them.

  • Four consecutive season openers have been missed by Florida State.

  • Since 2017, the Seminoles are 5-14-1 ATS as underdogs.

  • Since 2019, the Seminoles have gone 0-6 ATS in games against nonconference opponents.

The college football picks against the spread is a weekly article that gives out betting nuggets for college football games.

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